02 / Our technology

PerturbSeek: a digital life world model ecosystem

Across the modalities and scales of living systems, PerturbSeek builds digital life world models, simulates state changes and identifies effective interventions. AlphaCell is its virtual cell model.

  • 01Build world models
  • 02Simulate state changes
  • 03Identify interventions
View preprint
AlphaCellVirtual cell world model Coming soonMore models in development

AlphaCell / ARCHITECTURE

Cells are states. Interventions are flows

AlphaCell’s three core modules map to the three choices: see the whole cell, treat perturbation as flow, learn general dynamic laws.

Cell populations from many conditions mapped onto one continuous manifold and carried to predicted states

01 / REPRESENT

Virtual Cell Space

A genome-scale state manifold.

  • >220M single-cell expression profiles
  • 19,253 protein-coding genes
  • Topology-preserving latent representations

02 / SIMULATE

Dynamics Simulator

Optimal-transport flow matching.

  • Learned vector fields
  • Zero-shot transfer to new cellular contexts

03 / RENDER

Biological Renderer

A decoder with biological priors.

  • Genome-wide expression profiles
  • Decoded once, at the end

AlphaCell / GENERALIZATION

Generalizable cell-state simulation

AlphaCell’s generalization is tested at three levels, each farther from the training data.

CellseenunseenanyPerturbationseenanyPairingseenunseenany

One tile = one pairingSeen in trainingNot seen in trainingPredicted at this level

PerturbSeek / AlphaCell 1.0

The AlphaCell 1.0 model family

AlphaCell is the virtual cell state simulation world model in PerturbSeek. The founding team released AlphaCell 1.0 Preview in March 2026. AlphaCell 1.0 Pro is a full upgrade built on it, and can be trimmed down to Flash or scaled up to Mega to match each customer and pipeline.

01Preview

2026.03Released

AlphaCell 1.0 Preview

Built on geometric world models.

View preprint
02Flash

300MParameters

AlphaCell 1.0 Flash

Lightweight, private deployment.

03Pro

1BStandard parameters

AlphaCell 1.0 Pro

Accuracy with efficiency.

04Mega

50BParameters

AlphaCell 1.0 Mega

Large-scale perturbation simulation.

01

Parameter sweet spot

Bigger is not always better: we balance performance, cost and efficiency.

02

China-native compute

The PerturbSeek engine runs full-stack on Chinese GPUs.

AlphaCell 1.0 Preview

As virtual cell models compete ever harder worldwide, its geometric world-model architecture stands out, and Nature reported on it as a representative virtual cell world model.

AlphaCell 1.0 Flash

Trims down to a 300M lightweight model, suited to lightweight and private deployment at hospitals, research institutes and small and mid-sized pharma.

AlphaCell 1.0 Pro

At a standard 1B parameters, it keeps biological predictions accurate while staying efficient in compute and development, and scales elastically on demand.

AlphaCell 1.0 Mega

Scales up to 50B parameters, giving large multinational pharma (MNC) system-level perturbation simulation for complex scenarios.

The series covers our main commercial settings: model service subscriptions, private deployment and co-development of high-value pipelines.

AlphaCell / PREPRINT

bioRxiv / DOI 10.64898/2026.03.02.7091762026

Towards building a World Model to simulate perturbation-induced cellular dynamics by AlphaCell

A proof-of-concept generative Virtual Cell World Model unifying a continuous Dynamics Simulator with a high-fidelity Biological Renderer.

View preprint

Coming soon

More modalities and scales

Beyond the virtual cell, PerturbSeek is building world models for more modalities and scales of living systems.

Get in touch

Next chapter

03Partnerships

From disease mechanism to drug pipeline.